Perception of your own definition of bronchopulmonary dysplasia towards the neurodevelopmental consequences

Perception of your own definition of bronchopulmonary dysplasia towards the neurodevelopmental consequences

Understanding the short and long-term pulmonary and neurologic outcomes of neonates with bronchopulmonary dysplasia (BPD) is important in neonatal care for low-birth-weight infants. Different criteria for BPD may have different associations with long-term outcomes. Currently, two criteria for diagnosing BPD have been proposed by the NIH (2001) and NRN (2019) for preterm infants at a postmenstrual age (PMA) of 36 weeks. We investigated which BPD definition best predicts long-term outcomes. Korean nationwide data for preterm infants born between 24 +0 and < 32 +0 weeks gestation from were collected. For long-term outcomes, severity based on the NRN criteria was significantly related to neurodevelopmental impairment (NDI) in a univariate analysis after other risk factors were controlled. For the admission rate for respiratory disorder, grade 3 BPD of the NRN criteria had the highest specificity (96%), negative predictive value (86%), and accuracy (83%). For predicting NDI at the 18–24 month follow-up, grade 3 BPD of the NRN criteria had the best specificity (98%), positive (64%) and negative (79%) predictive values, and accuracy (78%) while NIH severe BPD had the highest sensitivity (60%). The NRN definition was more strongly associated with poor 2-year developmental outcomes. BPD diagnosed by NRN definitions might better identify infants at high risk for NDI.


Bronchopulmonary dysplasia (BPD) is actually a primary risk for the very low delivery lbs infants (VLBWIs). Much more serious BPD are regarding the an elevated odds of developmental impairment and you can reduced pulmonary mode step one,2,step 3 . Medical course of the disease, such as the importance of rehospitalization and you will neurodevelopmental handicap, are a documented matter certainly one of mothers and you can medical care team 4 . Finding out how situation seriousness is for the developmental decelerate and you may readmissions might help book upcoming lookup and you can high quality improvement attempts to minimize the burden of the issues.

BPD was defined by Northway ainsi que al. 5 more than 50 years ago; but not, when you look at the 2001, the brand new National Institute off Boy Fitness (NIH) modified this new categorical significance out of BPD. Now, inter-cardio variability inside clean air management and you can nose cannula circulate, along with the access to noninvasive ventilation, is prejudice this new NIH category from BPD exposure and you can seriousness. This means that, these types of widely used criteria may not be appropriate for the present day medical situation or the forecast out-of long-title effects of contemporary VLBWIs 6,7 . In line with this difference, Jensen et al. 8 advised a separate concept of BPD one to most useful predicted early youngsters morbidity and categorized state severity according to setting out of breathing support, whatever the accessibility extra fresh air. This meaning is revised to even more precisely assume breathing readmission and developmental waits during the an excellent U.S.-born population.

And therefore, we lined up to decide and that definition of BPD from the good PMA out of 36 months is actually most suitable for anticipating much time-title neonatal consequences, particularly pulmonary and you may neurologic effects, measured from the 18–24 months remedied years (CA), in the a great multicenter cohort examination of VLBWIs in line with the across the country Korean Neonatal Circle (KNN) registry.


A maximum of 8294 babies born ranging from twenty four +0 days and 29 +six months GA was indeed entered with the KNN, Once excluding babies, 2889 VLBWIs stayed; among them, 1849 (64.0%) got complete follow-up suggestions offered at California secret benefits 18–a couple of years, as well as respiratory readmission and you will developmental outcomes (Fig. 1). Of these 1849 VLBWIs, 1221 (66.0%) had BPD with respect to the NIH definition, including 665 children (36%) having light BPD, 184 babies (10%) having reasonable BPD, and you will 372 infants (19%) that have significant BPD. Having said that 555 kids (30%) got BPD according to NRN meaning, together with 186 infants (10%) having grade step one BPD, 303 babies (16%) having values dos BPD, and you may 66 children (4%) with levels step 3 BPD (Dining table 1).

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